PSMA brings new flavors to PI3K signaling: A role for glutamate in prostate cancer.
نویسندگان
چکیده
In this issue of JEM, Kaittanis et al. (https://doi.org/10.1084/jem.20171052) report a new signaling role for prostate-specific membrane antigen (PSMA), providing a mechanistic link between two major oncogenic pathways, as well as promising therapeutic implications for the diagnosis and treatment of prostate cancer.
منابع مشابه
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in prostate cancer remained elusive. Filling this gap, we demonstrate that in prostate cancer, PSMA initiates signaling upstream o...
متن کاملPsMA br ings new flavors to Pi3K signaling: A role for glutamate in prostate cancer
Aberrant regulation of the androgen receptor (AR) pathway is one of the main drivers of tumorigenesis in prostate cancer and has been a promising therapeutic target in recent years (Ferraldeschi et al., 2015). Tumor growth is highly dependent on androgens, as activation of AR triggers the increased transcription of genes involved in cell growth and metabolism. Prostate cancer progresses through...
متن کاملPsMA br ings new flavors to Pi3K signaling: A role for glutamate in prostate cancer
Aberrant regulation of the androgen receptor (AR) pathway is one of the main drivers of tumorigenesis in prostate cancer and has been a promising therapeutic target in recent years (Ferraldeschi et al., 2015). Tumor growth is highly dependent on androgens, as activation of AR triggers the increased transcription of genes involved in cell growth and metabolism. Prostate cancer progresses through...
متن کاملPsMA br ings new flavors to Pi3K signaling: A role for glutamate in prostate cancer
Aberrant regulation of the androgen receptor (AR) pathway is one of the main drivers of tumorigenesis in prostate cancer and has been a promising therapeutic target in recent years (Ferraldeschi et al., 2015). Tumor growth is highly dependent on androgens, as activation of AR triggers the increased transcription of genes involved in cell growth and metabolism. Prostate cancer progresses through...
متن کاملPsMA br ings new flavors to Pi3K signaling: A role for glutamate in prostate cancer
Aberrant regulation of the androgen receptor (AR) pathway is one of the main drivers of tumorigenesis in prostate cancer and has been a promising therapeutic target in recent years (Ferraldeschi et al., 2015). Tumor growth is highly dependent on androgens, as activation of AR triggers the increased transcription of genes involved in cell growth and metabolism. Prostate cancer progresses through...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of experimental medicine
دوره 215 1 شماره
صفحات -
تاریخ انتشار 2018